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Another methodological consideration is the use of a computerized analysis for FST that was developed in our laboratory to continuously follow the limbs of rats 35 and detect fine alterations in mobility throughout the test

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GI AEs were most prevalent during or shortly after dose escalation, declining in prevalence thereafter

Fasting state also matters, as insulin elevation (from a recent meal) suppresses GH release

Patients seeking the highest level of weight loss may be better candidates for tirzepatide