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Such multifaceted actions position MOTS-c as a compelling molecule of interest for managing obesity and metabolic dysfunction (though currently these effects have been demonstrated in preclinical research models)

When compared to matched normal thyroid tissue, both benign (human follicular adenomas, or FTAs) and malignant (follicular (FTC) and papillary thyroid carcinoma (PTC)) lesions were found to have elevated nuclear levels of 8-oxo-dG (118) which most likely reflects the detrimental effects of prolonged exposure to chronic OxS seen during thyroid cancer (118)

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