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Materials and methods This study was approved by the Vice-Chancellor in Research Affairs -Medical University of Isfahan (Biomedical Research Ethics Committee) (approval code: IR.MUI.RESEARCH.REC.1400.037, March 2021)

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Severe gastrointestinal adverse reactions may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal impairment, requiring close monitoring of fluid status and kidney function