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McCoy and colleagues reported that 5-day treatment of dissociated rat hippocampal neurons with Dihexa increased dendritic spine density approximately three-fold compared to vehicle control (~41 spines per 50 m of dendrite versus ~15 spines), with the increase reflecting both new spine formation and increased spine-head width consistent with synaptic maturation [2]

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While direct mutagenic effects were not identified in safety studies, proliferative effects were, representing a plausible pathway for increased risk of PDAC

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These results led the FDA in 2024 to approve Wegovy, initially green-lit for weight loss, for a second indication: to reduce the risk of serious heart problems in adults with cardiovascular disease who are overweight or have obesity