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J Integr Med 21(5):464473 Acknowledgements The authors would like to acknowledge the support provided by the School of Basic Medical Sciences at Ningxia Medical University, Ningxia Natural Science Foundation and the Key Laboratory for the Prevention and Control of Common Infectious Diseases

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501,553 In parallel with the impaired de novo pathway, the NAD + decline in the ALS might also be due to the inadequate NAMPT-mediated NAD + salvage synthesis pathway