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In the SURMOUNT-5 trial, which directly compared the two, Mounjaro produced a 20.2% weight loss, compared with 13.7% for semaglutide 2.4 mg over 72 weeks

By enhancing insulin secretion, inhibiting glucagon release, and slowing gastric emptying, GLP-1 receptor agonists help control blood glucose levels effectively

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Sustained depletion of NRF2 upon Gclc deletion induces a sex-dependent requirement for NRF2 to maintain liver homeostasis and animal survival Liver-specific deletion of Gclc impaired the expression of lipogenic enzymes and lowered circulating triglyceride levels

doi: 10.15167/2421-4248/jpmh2022.63.2S3.2766