New or intensified physical activity can cause muscle soreness and stiffness, which might be mistaken for medication side effects
In the pivotal SURPASS clinical trial program evaluating tirzepatide for type 2 diabetes, arthralgia was documented as an adverse event, but occurred at similar rates in both tirzepatide and comparator groups, suggesting it may not be directly attributable to the medication itself
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Taken together, the effect of OXPHOS perturbation varied according to the affected OXPHOS complex and the target tissue
But it does mean clinicians have a much clearer understanding of who it helps, how it works, what side effects are common, and where the safety boundaries are
HUBERMAN: Or that testes