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You may be ready to stop or down-titrate if: Cycles are regular (2635 days) Ovulation is consistent Luteal phase is stable (1014 days) Weight loss is ~510% Metabolic markers have improved At this point, the primary fertility benefit of GLP-1s has likely been achieved

Retrieved 12 July 2026

A separate 2025 trial in NEJM Evidence (Shah et al.) in adults with T1D and obesity on AID found that around one in three semaglutide-treated participants met a combined goal of improved time in range, low hypoglycemia, and at least 5% weight loss

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In clinical trials, it took 68 weeks for the average study participant to lose 33 pounds on a 2.4mg dose of semaglutide, the active ingredient in Ozempic

This not only reduces the burden of travel but also makes it easier to stay consistent with treatment