glp-1 and insulin Receptor Agonists Schematic of action of GLP-1

In the landmark STEP 1 trial, patients treated with once-weekly semaglutide achieved an average weight loss of 14.9% of body weight over 68 weeks (Wilding et al., New England Journal of Medicine , 2021)

Case Rep Psychiatry

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Reaction 1: Glucose-6-Phosphate (G6P) + NADP 6-Phosphogluconolactone + NADPH + H In this reaction, NADP acts as an electron acceptor, and G6PD oxidizes G6P, resulting in the release of NADPH and a proton (H)

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collagen synthesis at the cellular level (essential for maintaining firmness and elasticity)