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Horm Res 51 : 7884 Goodman HM (1968) Growth hormone and the metabolism of carbohydrate and lipid in adipose tissue

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It does this in 3 main ways: 1) it boosts the release of insulin, which increases the uptake of sugar from the blood to the cells, and inhibits the release of glucagon, which raises the concentration of glucose in the blood 2) it slows stomach emptying and increases fullness and 3) it acts on the brain to reduce appetite and cravings

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Rapidly increasing energy metabolism in vulnerable individuals can lead to adverse effects, such as mania or psychosis