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For Mounjaro and Wegovy to be most effective, you need to follow a diet and exercise program

The body weight of the FcLep group remained comparable to vehicle control due to leptin resistance

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Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: A Phase 1b, multicentre, blinded, placebo-controlled, randomized, multiple-ascending-dose study in people with type 2 diabetes

This is called a calorie deficit

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