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Esta es la lesin pigmentada ms frecuente de la mucosa y su estudio histolgico demuestra la presencia de pigmento pardo a lo largo de fibroblastos y en la periferia de vasos sanguneos, con escasa reaccin inflamatoria en la mayora de los casos

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Similarly, the mutation of W1246 led to a loss of drug resistance and specifically affected the transport of organic anions (Zhang et al., 2004)

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