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(2006) 83:456S60S

HIF-1: hypoxia inducible factor-1

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"Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer." Nature Reviews Drug Discovery, 6(10), 821-833

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The molecular mechanisms primarily involve excessive activation of the unfolded protein response triggered by endoplasmic reticulum stress in granulosa cells [350], leading to caspase cascade-dependent apoptosis, as well as DNA strand breaks and membrane lipid peroxidation induced by mitochondrial electron transport chain leakage in spermatozoa [351, 352]