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Liver, kidney and allergic reactions have been reported with other forms (NOT methylcobalamin) of B12

Blood was collected at 0.25, 0.5, 1, 2, 4, 8, 24 and 48 h for subcutaneous and oral gavage groups

To address these limitations, composite nanocarrier systems combining multiple polysaccharides have been developed, effectively overcoming the weaknesses of single-component carriers (182, 183)