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The researchers evaluated changes in muscle quality, quantity and function, focusing on the psoas, a pair of large core muscles that run from the lower back, through the pelvis, to the thigh bone

This upregulation was achieved by elevated levels of ERK, c-Fos, NF-B p65, NF-B p50, and CUX1, all factors known to bind to the promotor of TNF and IL-6 (180)

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Additionally, patients with estrogen deficiency may experience more rapid muscle loss during weight reduction unless this is proactively addressed