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12 GM-targeted therapies: clinical evidence and critical evaluation Deriving from the existing comprehensive studies on the gut-bone axis, the modulation of the GM presents a promising and increasingly evidence-based strategy for the management of OP in clinical settings

Participants were aware of the treatment they were receiving

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It has been speculated that the continued use of bethanechol may result from its use in patients who find the option of undergoing urinary catheterisation intimidating & choose to exhaust less invasive treatment options first, or in select patients where it seems to provide a marginal benefit (Gaitonde et al, 2019)