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Evidence for the involvement of mitochondrial radical generation

Hierarchy of Evidence: Level D (In vitro and rodent models)

We've said it before, and we'll say it again

Recently, studies have shown that eradication of HCV infection (with direct-acting antivirals) improves IR and thereby reduces the chance of developing diabetes and cardiovascular disease

Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise

15 The gene for glutathione peroxidase-4 is expressed in most tissues, including the brain (Gene Expression Atlas, available at Although the GPX4 gene is highly polymorphic, a limited number of studies 16, 17, 18, 19 have been done to investigate genetic variations within the GPX4 gene that could potentially alter the function of the enzyme