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When the conversion of propionyl-CoA to succinyl-CoA in the mitochondria fails due to Vitamin B 12 deficiency, elevated blood levels of methylmalonic acid (MMA) occur

At present, carnitine has many functions, including reducing oxidative stress, increasing expressions of pro-inflammatory cytokines (2527), improving mitochondrial dysfunction (28) and insulin resistance (29, 30)

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"Also, while the association we found raises safety concerns about the widely used supplement, our study cannot prove a direct cause-and-effect relationship