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Age-associated changes of cytochrome P450 and related phase 2 gene/proteins in livers of rats

A key principle in network pharmacology is the development of intricate networks that illustrate the connections between phytochemicals, genes, proteins, and diseases

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Among these, adiponectin is a hormone able to exert an insulin-sensitizing effect by binding to its receptors and to activate post-receptor signaling pathways mainly mediated by adenosine monophosphate dependent kinase (AMPK) and by peroxisome proliferator-activated receptor (PPAR)- [113]