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This suggests that semaglutide may cause early worsening of DR, especially in patients with poor glycemic control, highlighting the importance of monitoring DR during GLP-1 RA therapy

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In clinical trials of Wegovy, this has led 4% to 17% of people to stop taking semaglutide for weight loss

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Moreover, Aib significantly promotes the formation of alpha helices within the peptide structure, which enhances the molecules enzymatic stability and potency without significantly altering the structural integrity of the native peptide [16]