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However, if you take additional medications metabolized by these pathwaysstatins, certain antidepressants, or beta-blockersberberine may elevate their concentrations, increasing side effect risk and requiring dose adjustments
But there are two differences: 1) They are approved for two different (but related) reasons
[167] Additionally, research on the neurobiological effects of physical exercise suggests that daily aerobic exercise, especially endurance exercise (e.g., marathon running), prevents the development of drug addiction and is an effective adjunct therapy (i.e., a supplemental treatment) for amphetamine addiction
doi:10.1038/pcan.2017.19
patients continue therapy as long as they tolerate it and benefit clinically