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Aim for 2.5-3 liters of water daily during active episodes
People with diabetes also need medication review because insulin, sulfonylureas, and appetite changes can interact in clinically important ways
For patients seeking additional weight loss, microdosing is generally less effective than standard therapeutic dosing
Statements Author contributions SL: Writing original draft
Starting GLP-1 use with shared decision-making Like many medicines and treatments for chronic illnesses, the use of a GLP-1 is a decision that patients should make with the guidance of their providers
There is also a trial specifically testing whether retatrutide prevents heart attacks and strokes (TRIUMPH-3, 1,800 people), and a head-to-head trial comparing retatrutide directly against tirzepatide (the active ingredient in Zepbound) under identical conditions (NCT06662383, 800 patients)
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