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Pyruvate carboxylase catalyzes the carboxylation of pyruvate to oxaloacetate

These two enzymes use GSH to convert toxic MG and other 2-oxoaldehydes to their 2-hydroxyacids

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Furthermore, their small size allows for easy synthesis and modification, facilitating their incorporation into drug-delivery systems or peptide-based therapeutics

2 Although EH is frequently complicated by cerebral stroke (CS), there are many patients who did not suffer the cerebrovascular disease suggesting genetic susceptibility to stroke in some, but not in all hypertensive individuals

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