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McCormick WJ

During the bioleaching process, the released heavy metals are toxic to the leaching microorganisms, and the stress tolerance process of the microorganisms will result in the production of reactive oxygen species (ROS) inside the cells (Stadtman and Oliver, A

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The skin in these areas has been stretched over time and may not snap back fully after significant weight loss, particularly in older patients or those who lost weight quickly

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Gradual tapering (reducing dose over 4-8 weeks) may reduce appetite rebound intensity compared to stopping abruptly, though both approaches carry weight regain risk