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Isshiki, et al

[76] Dopamine agonist such as levodopa: One of levodopa's chronic side effects in Parkinson's patients is the "on-off phenomenon" of motor fluctuations - periods of oscillations between "on", where the patient experiences symptomatic relief, and "off", where the therapeutic effect wears off early

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Cetirizine is metabolized partially by oxidative O-dealkylation to a metabolite with insignificant antihistaminic activity

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