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Retatrutide storage requirements Retatrutide is still in clinical trials and primarily available as a research compound

Replacement with Trp 7 lowers the affinity (IC 50 : 0.26 nM3.3 nM) and strongly lowers the activity (EC 50 : 0.8 nM127 nM)

SUSTAIN-6 (semaglutide) [53], PIONEER 6 (semaglutide) [61], and LEADER (liraglutide) [54] looked at similar patient populations (over 50 years old with established cardiovascular disease) and found that GLP-1RAs produce a cardiovascular protective function relative to primary endpoints (Table 1)

EClinicalMedicine 57:101865

Doytchinova et al., 2020)

31.6% of cagrilintide participants achieved greater than 15% weight loss, compared to just 4.7% on placebo