Therefore, further investigation is warranted through large-scale, extended-duration, monotherapy-focused Phase III trials to corroborate these findings and establish definitive efficacy and safety parameters (145)
The animal findings on dopamine system preservation are intriguing given the aging-related decline in dopaminergic tone that contributes to motor and motivational deficits in older adults, but this application should be considered speculative pending human data
Structure Therapeutics (16 March 2026)
While this is a necessary first step, it frequently creates highly reactive, electrophilic intermediate metabolites that are actually more toxic and dangerous than the original parent compound
doi: 10.1016/j.fct.2008.12.007 167
Homocysteine Metabolism : Elevated levels of homocysteine, which can occur in vitamin B12 deficiency, are generally associated with neurotoxicity and it can increase the risk of neurodegenerative diseases