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574 Second-line treatments involve intracavernosal injections of alprostadil for those unresponsive to oral medications and the use of vacuum erection devices, which are non-invasive methods to engorge the penis with blood

They help lower blood sugar by stimulating insulin release, but until now it has remained unclear how they also strengthen the mitochondria, the tiny energy-producing structures that keep -cells functioning and resilient

We speculate that this provides targetable insight into the metabolic mechanism of HR-proficient resistance to DNA damaging agents

2025;45:e70006

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