[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Mobasher MA, Gonzalez-Rodriguez A, Santamaria B, Ramos S, Martin MA, Goya L, Rada P, Letzig L, James LP, Cuadrado A, Martin-Perez J, Simpson KJ, Muntane J, Valverde AM.Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity
Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome
SCFAs are capable of traversing the blood-brain barrier to modulate central nervous system (CNS) activity, while dysregulation of microbiota-derived neurotransmitters, such as gamma-aminobutyric acid (GABA) and dopamine, is implicated in CNS disorders, including schizophrenia 35
A mild model may see very little benefit
Looking ahead, NASH trials ought to incorporate a thorough evaluation of the systemic drivers, modifiers, and manifestations of the disease
TaylorEBAnDKramerHFYuHFujiiNLRoecklKSet al
