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Understanding the role of functional folate deficiency in these symptoms highlights why standard folic acid supplementation may not be enough for those with an MTHFR mutation

One outlier was removed from the vehicle, MK-801 and GLP-1MK-801 groups due to deviation related to tissue processing

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This is particularly alarming as EOT2D is characterised by a high-risk phenotype, with diagnosis of T2DM at an earlier age associated with a higher risk of micro- and macrovascular disease [1,7-10], accelerated ageing [11], and increased risk of mortality in comparison to later-onset T2DM [7,8,12,13]