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This is further buoyed by the varied and numerous clinical symptoms of the conditions

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Uncontrolled diabetes

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While the development of glucagon-like peptide-1 receptor agonists (GLP-1RAs) has expanded diabetes care, the bulk of the literature on these medications derives from tightly controlled clinical trials (e.g., Phase III trials such as the global PIONEER program), with only a few studies investigating their real-world effectiveness

This high degree of functional flexibility poses challenges for therapeutic exploitation: when designing SQOR-targeted interventions, one must consider that SQOR may have diametrically opposite effects in different contexts to avoid unintended disruptions of the broader sulfur metabolic network