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Expiry Date: 04 May 2027

The VHL protein maintains oxygen homeostasis by regulating HIF ubiquitination and degradation

[19] [20] Clinical trials show Zepbound reduces systolic blood pressure by 6-8 mmHg and diastolic pressure by 2-4 mmHg on average over 72 weeks

This effect directly opposes Wegovy's appetite-suppressing mechanism, potentially reducing the medication's effectiveness in promoting weight loss

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