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In particular, the Nlrp3 inflammasome is a cytosolic multiprotein complex expressed in immune/inflammatory cells as well as cardiovascular system cells, including endothelial cells, myofibroblasts/fibroblasts, and cardiomyocytes, which, through the processing and release of interleukin (IL)-1 and IL-18 and the induction of cell death processes (pyroptosis, apoptosis, and necroptosis), plays a key role in the maintenance of host homeostasis and in sustaining the pathophysiological events underlying CVDs (48)
10.1016/j.chemosphere.2010.10.070 Chemosphere 68 ReymondP.WeberH.DamondM.FarmerE
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The high efficiency of the method allows the profiling of drugprotein interactions at physiologically relevant drug concentrations inside the cell
Diabetes Care 24 , 371381 (2001)
