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Meaningful body-weight reductions , though slightly less than in non-diabetic participants a trend also seen with injectable GLP-1 receptor agonists These results show why orforglipron is being closely monitored as a potential long-term oral GLP-1 medication for weight management and metabolic health

A study investigated whether weight loss was sustained better one year after termination of a GLP-1, supervised exercise program, or combined for one year (4)

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