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Repurposing of already approved drugs has been explored, for example, disulfiram, a drug traditionally used to treat alcohol dependence, can lower cystine levels in cystinotic cells, but has side effects that limit its use in cystinosis [151, 153]

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In fact, ambient intracellular oxidants (i.e., H 2 O 2 ) can regulate various signal transduction pathways by reversibly oxidising cysteine residues in several proteins, thus modulating their activities [3]