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Statistical Analyses Mean HbA1c and weight changes from baseline were estimated using an analysis of covariance (ANCOVA) model

Future trials should be structured to assess whether initiating treatment in high-risk, cognitively unimpaired individuals (e.g., those with type 2 diabetes mellitus, obesity, and/or specific genetic risk factors such as APOE4) can delay or prevent cognitive decline onset

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These findings expand the peptides therapeutic potential beyond longevity, supporting its role in functional preservation of vision and neurological health

& Guan, K

KPV's anti-inflammatory mechanism complements the gene-expression, angiogenic, and cell-migration mechanisms of the other three peptides