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Identification of continuous baseline variables predicting drug response We used XGBoost (extreme gradient boosting), an ensemble machine learning technique based on several sequential decision trees, to identify continuous baseline variables predicting the change in HbA1c, BMI and systolic blood pressure after treatment with the study drugs

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Long-term post-market surveillance continues to monitor for any emerging signal, and no thyroid malignancies were linked to tirzepatide in SURMOUNT trial participants

Angioedema is caused by an increase in local capillary permeability and plasma extravasation, usually mediated by mast cells, histamine, or bradykinin release

Obesity and diabetes cause hyperglycemia, which causes metabolic dysfunction, leading to the growth and proliferation of cancer cells

(December 19, 2025)