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The method can solve the hydrophobic property of the PS resin and avoid peptide chain aggregation in the peptide chain extension process, thereby solving the problems of difficult residue solid-phase coupling and lower yield of the semaglutide sequence caused by beta-folding, simultaneously solving the problem of difficult coupling of a semaglutide side chain long-chain fatty chain caused by strong hydrophobicity, and greatly improving the coupling effect of octadecanedioic acid

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The NLRP3 inflammasome stimulation by sUA is accompanied by cellular redox state changes, increasing in mitochondria area and mitochondrial ROS production

Science 374 , 10761080 (2021)

Overall, the study underscores the functional relevance of the extrinsic apoptotic pathway in RBC senescence and clearance