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In preclinical models of polymicrobial sepsis, such as the cecal slurry and cecal ligation puncture (CLP) models, long-acting GLP-1 receptor agonists (GLP-1RAs) like semaglutide have demonstrated protective effects
Johnson B et al
According to the Semaglutide Treatment Effect in People with Obesity (STEP) program studies, people with overweight or obesity (without T2DM) who received semaglutide 2.4 mg and underwent lifestyle interventions experienced an average weight reduction of 14.7- 17.4% [116]
Following the recommended slow dose titration protocol and implementing dietary modifications substantially reduces the incidence and severity of gastrointestinal side effects
These included reproductive symptoms, including irregular menstrual cycles and unexpected bleeding, and temperature-related issues, such as chills, hot flashes, and feeling unusually cold
