4.2 Potential of other neurotrophic factors Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with a wide range of biological actions that positively affect the viability, proliferative activity, and migratory ability of cells in the nervous system (Revishchin et al., 2022)
doi: 10.1016/j.pmpp.2015.09.001 34 HernndezJ
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NHS: [accessed 26 January 2026] EMC (2022)
Study design RCTs, systematic reviews, meta-analyses, observational studies, and mechanistic preclinical studies
The clinical expert stated that expected use of semaglutide tablets is aligned with the indication and that semaglutide tablets would be used as an add-on treatment in patients with T2DM when metformin is no longer effective as monotherapy (second-line treatment), as a first-line treatment when metformin is not tolerated, and as a third-line treatment on occasion