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These irAEs usually appear 39 weeks after treatment initiation and often resolve within two weeks with appropriate management

doi: 10.3389/fimmu.2024.1440313 Received 30 May 2024 Accepted 18 November 2024 Published 05 December 2024 Volume 15 - 2024 Edited by Xing Wang, The Affiliated Hospital of Southwest Medical University, China Reviewed by Christoph Hudemann, Philipps-University Marburg, Germany Franziska Roth-Walter, University of Veterinary Medicine Vienna, Austria Updates Copyright 2024 Biedrzycki, Wolszczak-Biedrzycka, Dorf and Maciejczyk

This supports our findings where MTX injection evoked oxidative stress with augmented hepatic lipid peroxidation product while declining hepatic antioxidant capacity as depicted by lower GSH and SOD

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