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PLoS One 7 , e43030 (2012)

This class of compounds binds to key receptors in the brain, pancreas, and gastrointestinal (GI) tract, instigating several biological reactions: Enhances insulin secretion Slows gastric emptying Increases -cell proliferation Reduces glucagon release Mitigates hunger signaling These actions combine to regulate appetite, food intake, and the physical feeling of fullness (satiety)

Acknowledgments The authors gratefully acknowledge and thank the study participants and staff who assisted with the conduct of the trial and data collection

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In addition to drug trafficking, pharmaceutical crime is of interest to organized criminal groups, and many factors contribute to the falsification of medicines