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Activated SIRT1 deacetylates PGC-1 resulting in increased transcriptional activity and thus, enhanced mitochondrial biogenesis Therapeutic Intervention for Hyperglycemia Many, if not all, of the vascular consequences of insulin resistance are due to the persistent hyperglycemia seen in type 2 diabetes

Clinical studies in young (Lieberman et al

Furthermore, a moderate carnitine deficiency in congenital structural myopathies provides indications for carnitine supplementation

Benchmarking network propagation methods for disease gene identification

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