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Amylin has receptors in the kidney so the possibility of a direct effect on the kidney is very real

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Nat Rev Rheumatol (2020) 16(6):31633

By slowing down the process of gastric emptying, semaglutide lowers appetite and food consumption

Docusate is widely used, but clinical trials have not demonstrated meaningful benefit over placebo and it is less effective than fiber or osmotic laxatives