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Insulin glargine was given to female rats before mating, during mating, and throughout pregnancy at doses up to 0.36 mg/kg/day, which is approximately 50 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day)

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PGN cannot form gels because the molecules are not long enough to form meaningful helical structures due to their lower Mw (Blakemore 2015 Blakemore, W

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