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It may be related to the increase of oxidative damage, so the amount of GSH is a vital factor to measure the body's antioxidant ability

FANZCA and Goyen, Andrew K

Obesity treatment: breaking the 'energy intake expenditure deadlock' The essence of obesity is that energy intake exceeds energy expenditure for a long time, leading to excessive accumulation of adipose tissue

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We also discuss how modulation of the mitochondrial-inflammation axis informs conventional and emerging antidepressant strategies, aiming to advance mechanistic understanding and guide future clinical interventions

Diabetes Care 39 , 15871593 (2016)