While losing weight, you may not get sufficient fat to support physiological processes
Semaglutide works by mimicking the incretin hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying
When this hormone binds to receptors in the brain, pancreas, stomach, and elsewhere, several things happen: Appetite is significantly reduced, with many patients reporting a dramatic decrease in food cravings Gastric emptying slows, meaning food stays in the stomach longer and fullness is sustained after smaller meals Blood sugar regulation improves, reducing the energy spikes and dips that typically drive overeating Interest in high-calorie and highly processed foods often reduces, an effect many patients describe as the food noise quietening Mounjaro (tirzepatide) adds a second mechanism by also activating the GIP receptor
And it's better to talk to a doctor than pretend you're one yourself, agrees Howard Sklamberg, a former FDA deputy commissioner
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My dietitian, Kristen, and I, Ive been meeting for over two months or so, and I truly appreciate the guidance and concern concerns that she shares with me throughout the visit