The bottom line: Creatine is an affordable, safe, and well-tolerated adjunct that could help ensure weight loss is fat loss (not muscle loss) during treatment with GLP-1 receptor agonists and dual agonists
Porphyromonas gingivalis aggravates alcohol-related liver injury via gut microbiome-HO-1-ACSL4-dependent ferroptosis
Mean weight loss ranged from 9.1% at 2.5 mg to 14.7% at 15 mg, versus 1.7% on placebo, with no evidence of plateauing by the end of treatment (Figure 1)
Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK (2004) New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists
Such molecules elicit glycemic benefits in mice without concomitant increases in signs of nausea, a common side effect of GLP-1 therapies
FABP levels may vary according to disease severity as FABP1 protein levels were overexpressed in obese patients with steatosis ( n = 10) compared to obese controls ( n = 10), but decreased in NASH patients with mild fibrosis ( n = 10) and declining further in NASH with advanced fibrosis ( n = 10) [36]
