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U54HD061221), which is a part of the National Institutes of Health (NIH) Rare Disease Clinical Research Network (RDCRN), supported through collaboration between the Office of Rare Diseases Research (ORDR), the National Center for Advancing Translational Science (NCATS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and NIH K08DK106453

This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer

Calculate the total GSH equivalent intake to avoid excess

Accessed May 2023 at 3

Modification: Incorporates a disulfide bond for added structural integrity and extended durability under experimental conditions

Glutathione is made up of three amino acids: Glutamate, Cysteine and Glycine