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This research was approved by The Ethics Committee of Faculty of Medicine, Hasanuddin University

Srivastava KD, Bardina L, Sampson H, Li X-M

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2.3 Randomization Participants were randomized (1:1) using a pre-specified block randomization sequence (BABABAABAABBABBA), ensuring balanced allocation across treatment sequences

These nanoparticles typically have an average diameter between 50 and 1,000 nm (Paliwal et al., 2020)

Li et al., 2018), where it exerts its neuroprotective effects primarily by inhibiting the expression of pro-apoptotic factors such as Bax, caspase-3, and caspase-12, while promoting the expression of anti-apoptotic factors Bcl-2 and Bcl-xL